Chemistry for Life Sciences
The chemical synthesis of RNA is much more challenging that that of DNA. This is due to the necessity of completely protecting the 2’-OH groups throughout the various coupling steps as the oligomer is built up but then completely removed at the end without affecting any the RNA strand.
We are developing a novel 2’O-protecting group for phosphoramidite monomers used for chemical synthesis of RNA. This was funded by a SBIR grant, now pursued internally.
|Copyright 2007 Omm Scientific Inc. All Rights Reserved.