The chemical synthesis of RNA is much more challenging that that of DNA. This is due to the necessity of completely protecting the 2’-OH groups throughout the various coupling steps as the oligomer is built up but then completely removed at the end without affecting any the RNA strand.
We are developing a novel 2’O-protecting group for phosphoramidite monomers used for chemical synthesis of RNA. This was funded by a SBIR grant, now pursued internally.
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